Triple-negative transformation of the endometrium, cervix and mammary gland on the background of immunodeficiency

Precancerous processes of the female reproductive system continue to be an issue that is being actively studied, despite successes recent years. One key prognostic factors characterization receptor set, primarily mammary gland and endometrium, namely estrogen (ER), progesterone (PR), epidermal growth factor-2 (HER2) receptors. Purpose – identify features distribution estrogen, factor receptors in tissues cervix with a combination HIV infection alcohol abuse. Fifty women age from 20 40 years were studied. After routine conduction immunohistochemical staining, ER PR expression determined by modified D.Allred scale. HER2 was semi-quantitative method. The obtained digital data statistically processed. A morphometric study indicates abuse significantly affects system. To greater extent, overall score reduced reducing number cellular elements PR. endometrium gland. These changes may facilitated atrophic these organs, which occurs immunodeficiency. According scale, mean decreases 5.45±0.63 3.10±0.88 4.68±0.65 2.47±0.58 cervix, 6.57±0.67 3.57±0.77 (p<0.05). decreased 3.24±0.47 2.21±0.23 3.43±0.66 2.36±0.32 development immunodeficiency characterized restructuring organs change set decrease both qualitative quantitative composition receptors, serve as prerequisite for triple-negative phenomenon tumors organs.